Medicinal preparation



May 21 I UNITED STATES 1,114,420 PATENT OFFICE.

mmnu. w. mscnurz, or naooxmm, new voax, assmuon. To 3m SCIENTIFIC PRODUCTS (30., 1210.,

A CORPORATION 01' NEW YORK.

IEDICI'NAL PREPARATION.

Io Drawing.

This invention relates to a medicinal comound for the treatment of diseases of the iliary tract such as the liver, gall-bladder and biliary ducts. It has articu ar applica- 6 tion in assisting in the e imination of gallstones.

A great variety of substances have been proposed hitherto and have been tried and have been found not to give the desired re- 10 sults. Claims have been made that the administration of bile salts, phenolphthalein, calomel, olive oil, salicylates and Epsom salts will cause an elimination of the gall-bladder contents. They have each been tried and the 18 medical profession has come to the conclusion that none of the above substances are effective in causing the elimination of the contents of the gall-bladder.

Another method which until recently was believed to bring about the elimination of the contents of the gall-bladder was a mechanical method known as Lyons method, which involves the introduction of a tube per mouth reaching the duodenum, the tube containing 35 a dose of Epsom salts, this method also being accompanied by suction to remove the discharge of biliary duct into the duodenum. The medical profession has however, recently come to the definite conclusion that this method accomplished only the draining of the liver and does not affect the contents of the gall-bladder whatever.

Each of the substances and methods mentioned above, held vogue for a while in the medical profession until the recent development in cholecystography, known as Grahams method by which the gallbladder ma be visualized under an X-ray apparatus suc as a fluoroscope. By this method, the patient 40 is administered tetraiodophenolphthalein.- This substance is absorbed from the stomach into the liver whence it enters the gall-bladder with the bile. The bile in the gall-bladder thereby acquires sufficient density to cast a shadow on the X-ray film. By this method, it has become possible to definitely determine whether or not any of the substances or methods mentioned above known hitherto are effective in causing the elimination of the contents of the gall-bladder. Recent extensive experimentation has led the medical rofession to the conclusion that neither yons method, nor any of the substances;

mentioned above, have any effect upon the gall-bladder and do not bring about the elimi- 1 Application fled Kay 24,

oleic acid, will bring about an almost com- 1987. Serial ll'o. 198,950.

nation of its contents irrespective of the dose and the manner of administration.

It 1s the object of the present invention to provide a preparation or composition which w1ll bring about and facilitate the elimina- I t on of the contents of the gall-bladder in particular and of the biliary tract in general.

I have discovered that the administrationof oleic acid in doses offifteen minims in the form of gelatine capsules or otherwise brings about almost a com lete elimination of the contents of the gall-b adder and there by assists in the elimination of gall-stones and 1s generally beneficial in the treatment of the disease and of other diseases of the biliary tract. In some cases, depending u on the size and weight of the patient, more t an one dose is advisable but I have found that 1n all cases the administration of two to four capsules, each containing fifteen minims of plete elimination of the contents of the allbladder within two hours after the administration.

I have found that particularly desirable so and beneficial results are obtained in the treatment of diseases of the biliary tract when together with the oleic acid some bile salts are administered. For this purpose, my composition consists of a mixture of oleic and bile salts in the following proportions.

Sod. glycocholate grains Sod. taurocholate grains Oleic acid minims 15 The above composition 1s preferably put up in gelatinous capsules so that the salts as well as the oleic acid are administered per mouth simultaneously. In the treatment of gallstones as well as other diseases of the biliary 9 tract, the bile salts cooperate with the oleic acid to give highly beneficial results. The bile salts serve to actuate or stimulate the liver in the secretion of bile while the oleic acid serves by a process that is akin to peristalsis to milk the biliary tract so that while the contents of the gall-bladder is eliminated, the liver is stimulated so that shortly after the elimination of the gall-bladder con-- tents,a suflicient amount of bile is again secreted and deposited in the gall-bladder to perform its function.

I have further found that my preparation also assists in draining the pancreas. The manner in which the preparation brings 1 o about the draining of the pancreas is not fully known to me but it appears that it is due in part to the mechanical action of milking the duct connecting the pancreas with the duodenum and is in part due to a reflex action. I have further found that the introduction of oleic acid into the duodenum brings about an increased pancreatic flow.

I have demonstrated with the aid of'radiograms that when oleic acid is administered in the doses described hereinabove with or without the addition of bile salts, either a total or a partial emptying of the gall-bladder and bile ducts is accomplished within two This action or behavior of oleic acid hours. appears to be due to the mechanical effect of feet on the common bile duct, which effect is also transmitted to the cystic duct as wellas to the hepatic duct thereby emptying the gallbladder and ducts and ridding these organs of their contents. This process not only overcomes stasis in the biliary tract but also causes the expulsion of various pathological inflammatory products from these organs, such as inspissated bile, bile sand, and hard and soft gall-stones. Some of the substances which have previously been used for this purpose such as phenolphthalein, calomel, olive oil, or Epsom salts ave 'apparentl exerted a milking effect upon the common ile duct,

which for some reason or another, was not transmitted to the cystic duct and therefore never afi'ected the gall-bladder.

Under some conditions, I prefer the addition of phenolphthalein to the composition indicated above, approximately in the quantity of 1; grain. The addition of phenolphthalein in the quantity stated, in view of its laxative action, aids in the removal of the waste products from the intestines after these products have emptied from the biliary tract.

In lieu of phenolphthalein any one of a number of other laxatives may be substituted.

In my preferred preparation, the phenolphthalein is eliminated and one grain of dehydrated oxgall willbe substituted therefor. Inthis form of the preparation, the amount of bile salts is preferably increased. to grain each and its composition is as follows:

Sod. glycocholate grains 4 Sod. taurocholatm; grains Dehydrated oxgall grains 1 Oleic acid minims*15 Having described my invention, I do not wish to be limited to the specific composition or proportions recited hereinabove many departures withinthe spirit and scope of the appended claims from the specific compositions and proportions given above being obv vious to those skilled in the art. peristaltic activity in the duodenum caused by the oleic acid, this having a milking ef-1 I claim:

1. Amedicinal preparation for the treatment of diseases of the biliary tractcomprising oleic acid and bile salts.

. 2. A medicinal preparation for the treatment of diseases of the biliary tract comprising a gelatinous capsule containing 1 grains of phcnolphthalein, grains of sodium glycocholate, grains sodium ta-urocholate and oleic acid.

- 3. A medicinal preparation for the treatment of diseases of the biliary tract comprising a gelatinous capsule containing grains of sodium glycocholate, grains of sodium taurocholate, 1 grain of dehydrated oxgall, and 15 minims of oleic acid.

4.-. A medicinal preparation for the treatment of diseases of the biliary tract comprising a gelatinous capsule adapted to be administered per mouth, said capsule containing substantially fifteen minims of oleic acid for causing the elimination of the gall bladder contents, and from three-eightlis to onehalf grains of bile salts consisting of sodium glycocholate acid sodium taurocholate, the said bile salts cooperating with the oleic acid by stimulating the secretion of bile, whereby the gall bladder is subjected to repeated washings with an excessive amount of bile.

In testimony whereof I have hereunto affixed my signature.

EMANUEL W. LIPSCHUT Z. 

